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br Regulation of BCAA catabolism
2024-05-02
Regulation of BCAA catabolism The BCAA catabolic system is equipped in mammalian cells to dispose of excess BCAAs, presumably resulting in relatively stable concentrations of BCAAs in blood and tissues in humans. The main BCAA catabolic pathway is localized in the mitochondria of all tissues. The
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rolipram Heart failure is a chronic
2024-05-02
Heart failure is a chronic syndrome in which the heart is unable of pumping an adequate supply of blood to meet the metabolic requirements of the body or generating the required elevated ventricular filling pressures to maintain output [34]. Despite considerable advances in the treatment of heart fa
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The study by Lo http www apexbt com
2024-05-02
The study by Lowry et al. (2001) pointed toward functionally uncharacterized DA- and 5-HT-accumulating neurons within the DMH as a potential target for rapid nongenomic effects of CORT. Similar DA- and 5-HT-accumulating systems are distributed throughout the central and peripheral nervous systems, s
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Materials and methods br Results
2024-04-30
Materials and methods Results Discussion The BV-tag-based electrochemiluminescence immunoassay is an extremely sensitive assay. It has been employed for detecting analytes present in only picogram quantities (e.g., bacterial toxins [26], p2x receptors [19]), measuring the activity of basic c
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br ACh and ER tests hereafter Spasm
2024-04-30
ACh and ER tests hereafter Spasm provocation tests have self-limitations to document coronary artery spasm during daily life. In the past reports, ST elevation was reproducible in some patients with variant (+)-Catechin hydrate by the administration of ACh or ER. However, we now employ the ER and
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rilpivirine br Funding br Introduction l Dihydroxyphenylalan
2024-04-30
Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side
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cerk Overexpression of SMAD and SMAD strongly enhanced lucif
2024-04-30
Overexpression of SMAD3 and SMAD4 strongly enhanced luciferase activity of the new pN10 reporter gene construct which was further reinforced by addition of TGFβ. Serial mutations of SBE-1 and SBE-2 led to a slight loss in 5-LO promoter inducibility. The data demonstrate that the two SBEs within the
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Whereas more research is needed to
2024-04-30
Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the TAK-242 that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the behavi
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Several studies have demonstrated that depletion of
2024-04-30
Several studies have demonstrated that depletion of functional ATR increases the sensitivity of cancer cells to oncogene-induced replication stress thereby hindering tumour growth and inducing extensive cell death (Gilad et al., 2010, Murga et al., 2011, Schoppy et al., 2012). Importantly, Schoppy e
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In this review we will present the
2024-04-30
In this review, we will present the traditional and actual strategies to study orphan receptors and identify their ligands. An extensive description of the orphan GPCR field has been published in 2013 by Davenport et al. [22]. Therefore, we will focus on the deorphanizations that were reported since
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Antioxidative enzymes such as SOD and CAT
2024-04-30
Antioxidative enzymes such as SOD and CAT play prominent roles in protecting against oxidative stress and extending food freshness due to their ability in scavenging active oxygen species for maintaining cell membrane integrity. Evidence shows that activities of SOD and CAT are positively affected b
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Because of the critical roles
2024-04-30
Because of the critical roles played by AMPK in energy sensing and cancer cell survival, a huge number of drugs have been proposed to exert their pharmacological effects by means of AMPK activation (Kim and He, 2013). For example, metformin has been shown to activate AMPK in muscle (Sajan et al., 20
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This suggestion was confirmed by immunohistochemical studies
2024-04-29
This suggestion was confirmed by immunohistochemical studies in which the immunoreactivity of the enzyme was actually higher at the earlier rather than at the advanced stages of the disease. Importantly, a later study showed that the biochemical signature of 12/15LO enzymatic activation (i.e., 12-HE
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Some of the earliest LOX inhibitors were
2024-04-29
Some of the earliest 12-LOX inhibitors were redox inhibitors, including nordihydroguaiaretic nor-Binaltorphimine dihydrochloride receptor (NDGA), BW 755C, and baicalein 48, 49, 50. Redox inhibitors block the oxidation of the nonheme iron at the cataylytic site, preventing its conversion from the in
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The reactions and the control mechanisms
2024-04-29
The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of dpat cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of glucose b